• Home
  • News
  • Politics
  • Business
  • Entertainment
  • Education
  • Interviews
  • Sports
Facebook X (Twitter) Instagram
Trending
  • Poverty Deprives Developing Nations From AI Gains – YabaTech Don 
  • Lagos FA Chairman Hails Flying Eagles On World Cup Ticket; Congratulates NFF leadership
  • Sonupe Hails Tinubu’s Achievements; Praises Orelope-Adefulire, Bisi Yusuf; Pledges Support For Tinubu’s Re-election 
  • FG Announces Major Overhaul of Electricity Distribution Companies, Begins Pilot Scheme with 2 DisCos
  • LG Primary Polls: Lagos Inaugurates Appeal Committee; Pedro Is Chairman; Lanre Ogunyemi, Pelumi Members 
  • Embrace Benefits of straight, Healthy Teeth, Confident Smiles, Ajayi Advises Nigeria
  • 25 years After First Forensic Lab in Lagos, NDLEA Gets Two More in Abuja, Enugu
  • Sanwo-Olu: A Statesman as Governor
Facebook X (Twitter) Instagram
The Gazelle NewsThe Gazelle News
  • Home
  • News
  • Politics
  • Business
  • Entertainment
  • Education
  • Interviews
  • Sports
The Gazelle NewsThe Gazelle News
Home » Report: Scientists Develop ‘Groundbreaking’ Pills That Can Kill All Solid Cancer Tumors 
Health

Report: Scientists Develop ‘Groundbreaking’ Pills That Can Kill All Solid Cancer Tumors 

Khadijah OlowodeBy Khadijah OlowodeAugust 3, 2023No Comments0 Views
Facebook Twitter Pinterest LinkedIn WhatsApp Reddit Tumblr Email
Share
Facebook Twitter LinkedIn Pinterest Email

Scientists have developed a groundbreaking cancer drug that kills all solid cancer tumors while leaving other cells unharmed.

The new molecule, codenamed AOH1996 – targets a protein present in most cancers that helps tumors grow and multiply in the body. It is significant because this protein, the proliferating cell nuclear antigen (PCNA), was previously thought to be ‘undruggable’.

According to Mail Online, the drug was tested on 70 different cancer cells in the lab – including those derived from breast, prostate, brain, ovarian, cervical, skin, and lung cancer – and was effective against them all.

The drug is the culmination of 20 years of research and development by the City of Hope Hospital in Los Angeles, one of America’s largest cancer centers.

The good news comes months after scientists who invented the Pfizer Covid vaccine said that cancer will be curable within the coming decade.

The latest study, published in the journal Cell Chemical Biology, revealed that the new drug had been tested on more than 70 cancer cell lines and several normal human cells that did not have cancer but were used as a control.

The molecule selectively killed cancer cells by disrupting their normal reproductive cycle, preventing cells with damaged DNA from dividing, and stopping the replication of faulty DNA.

This combination of factors caused the cancer cells to die without harming healthy cells in the process.

The results will now need to be replicated in people. The drug is currently being tested on humans in a Phase 1 clinical trial at City of Hope.

Dr. Linda Malkas, Professor in City of Hope’s Department of Molecular Diagnostics and Experimental Therapeutics and the M.T. & B.A. Ahmadinia Professor in Molecular Oncology leads the team.

She explained how the molecule selectively disrupts DNA replication and repair in cancer cells, leaving healthy cells unaffected.

She said: “Most targeted therapies focus on a single pathway, which enables wily cancer to mutate and eventually become resistant.

“PCNA is like a major airline terminal hub containing multiple plane gates.

“Data suggests PCNA is uniquely altered in cancer cells, and this fact allowed us to design a drug that targeted only the form of PCNA in cancer cells.

“Our cancer-killing pill is like a snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells”.

Dr Malkas said results so far have been “promising’ as the molecule can suppress tumor growth on its own or in combination with other cancer treatments ‘without resulting in toxicity”.

The new therapy comes from 20 years of research and development and targets a cancerous variant of PCNA, a protein that in its mutated form is critical in DNA replication and repair of all expanding tumors, which helps cancers to repair and grow.

Study co-author associate research professor Dr Long Gu, said: ‘No one has ever targeted PCNA as a therapeutic because it was viewed as “undruggable,” but clearly City of Hope was able to develop an investigational medicine for a challenging protein target.

 derived from breast, prostate, brain, ovarian, cervical, skin, and lung cancer – and was effective against them all.

The drug is the culmination of 20 years of research and development by the City of Hope Hospital in Los Angeles, one of America’s largest cancer centers.

The good news comes months after scientists who invented the Pfizer Covid vaccine said that cancer will be curable within the coming decade.

Source: Daily Mail 

Cancer develop groundbreaking Kill scientists solid tumor
Share. Facebook Twitter Pinterest LinkedIn Tumblr Telegram Email
Khadijah Olowode

Related Posts

Embrace Benefits of straight, Healthy Teeth, Confident Smiles, Ajayi Advises Nigeria

May 12, 2025

25 years After First Forensic Lab in Lagos, NDLEA Gets Two More in Abuja, Enugu

May 12, 2025

Ex-Bayelsa MILAD Olubolade Dies At 70; How He Died – Children 

May 12, 2025

Leave A Reply Cancel Reply

© 2025 All Rights Reserved. The Gazelle News. Designed By DeedsTech.

Type above and press Enter to search. Press Esc to cancel.